A- International courses / conferences

2013:

• 29th Annual meeting of ESHRE, London, United kingdom, 3 to 6 July 2013.

2012:

• 1st Annual World congress of ICGO, Guangzhou, China, 2 to 4 December 2012
• 68th Annual meeting of ASRM, San Diego, USA, 22 to 24 October 2012.
• 28th Annual meeting of ESHRE, Istanbul, Turkey,1 to 5 July 2012.

2011:

• 27th Annual meeting of ESHRE, Stockhol, Sweden, 3 to 6 July 2011.

2010:

• Fertility Forum - SHAPE in clinic meeting, Ankara, Turkey, 2 to 3 December 2010.
• 26th Annual meeting of ESHRE, Rome, Italy, 27 to 30 June 2010.
• The subfertility and Reproductive Endocrinology course & The Assissted Conception Theoritical course. A collaborative course between the Royal Colleage of Obstetricians and Gynecologists and SMC. Alexandria, 26-30 April 2010.

2009:

• Intra-cytoplasmic morphologically selected sperm injection (IMSI) workshop held during the 16^th annual  meeting of MEFS. Cairo, Egypt, 6 of November 2009.
• 16^th annual meeting of MEFS. Cairo, Egypt, 4 to 7 November 2009.

2005:

• 12^th annual meeting of MEFS, Luxor, Egypt, 23 to 26 November 2005.
• Workshop on Reproductive Endocrinology and Molecular Biologyheld during the 12^th annual meeting of MEFS, Luxor, Egypt, 23 November 2005.
•  21th Annual Meeting of ESHRE, Copenhagen, Denmark, 20 to 22 June 2005.
• Certificate of accreditation of 11 - 13 +6 weeks Fetal Ultrasound Scanning, Fetal Medicine Foundation (FMF), linkoping University, Sweden, February 2005.
•  Training program on advanced gynecological cancer surgery, Lund University, Sweden, 10th - 24th January 2005.
•  Modern Management Training Program (MMTP) in Egypt, Morocco and Jordan on Health Care Quality Management, international workshop, 1st kick of and Steering Committee Meeting, 11-15 November 2004, Vaxjo University, Sweden.

2004:

•  20th Annual Meeting of ESHRE, Berlin, Germany, 27 to 30 June 2004.

2003:

• A joint meeting between The Society for the study of patho-physiology of pregnancy organization gestosis (OG), Basel, Switzerland (35^th international annual scientific meeting) and The International Fertility & the Egyptian ICSI Centers (8^th international annual scientific congress) Alexandria, 9th & 10th of October, 2003.
• The 2nd Annual Mediterranean Congress for Reproductive Medicine, Alexandria, 28th -30th of May, 2003

2002:

•  9th annual scientific congress of the Middle East Fertility Society (MEFS), Cairo from 1/11/2002 to 2/11/2002.

B- Local Courses/Conferences

2011:

•  25th Annual Scientific Conference of the Department of Obstetrics & Gynecology. Alexandria University,4-6 May 2011

2010:

•  The fourth Alexandria forum for women’s health and development. The Suzanne Mubarak regional center 24-25 March 2010

2008:

• The 1^st International Annual Conference for Gynecological Endoscopy, Alexandria Faculty of Medicine in collaboration with Egyptian Association of Gynecological Laparoscopies (EAGL), January 31th   – February 1^st , Convention Center, Alexandria Faculty of Medicine.
• 29th Annual scientific congress of Alexandria Faculty of Medicine “Future Medicine”14th-16th of May 2008.

2007:

• 28th Annual scientific congress of Alexandria Faculty of Medicine “Hospital and Healthcare Management”5th-6th of April 2007.
• Interactive presentation in medical education workshop, Faculty of Medicine, Alexandria University, 28th-29th March 2007.
• Alexandria forum for women’s health and development, Suzan Mubarak center, 21st -23rd March 2007.
• 3^rd annual scientific meeting “Updates in woman health”, Egyptian Post Fertility Society in collaboration with Arab Group of Menopause, Helnan Palestine Hotel, Alexandria, Egypt. 15- 16 March 2007.

2006:

•  27th Annual scientific congress of Alexandria Faculty of Medicine “Medical Research” 23th-24th of March 2006.

2003:

• Course of operative laparoscopy held in the Egyptian Association of Gynecologic Laparoscopists (EAGL) training center 20/9//2003 till 26/9/2003.
• Operative endoscopy workshop of the 8th Annual Congress of The Egyptian ICSI Centre, 11th- 12th of October 2003.

2002:

• MEFS Hysteroscopy Workshop, October 29th & 30th, 2002.
• Alexandria Fertility and Gynecology Forum by the Alexandria Fertility Center. Alexandria, March 7th & 8th, 2002.
• The First International Congress of Galaa Assissted Reproduction Unit (GARU), held in Cairo, MAY 23rd & 24th, 2002.
• 7th Annual Congress of the Egyptian ICSI Centre: New Frontiers in Reproductive Health. Alexandria December12th & 13th, 2002.

2001:

• 6th Annual Congress of the Egyptian ICSI Centre: New Frontiers in Reproductive Health. Alexandria November 1st & 2nd, 2001.
• Alexandria Fertility and Gynecology Forum by the Alexandria Fertility Center. Alexandria, March 22nd & 23rd, 2001.
• Training course for preparation of the university staff members by The University of Alexandria, October, 2001.

2000:

• 5th Annual Congress of The Egyptian ICSI Centre: Fertility Management: The road to success. Alexandria November 23rd & 24th, 2000.
• Alexandria Fertility and Gynecology Forum by The Alexandria fertility Center. Alexandria, March 30th & 31st, 2000.
• Workshop for Training of Trainers (T.O.T) For Obstetrics and Gynecology by The Ministry of health and population and JSI: Healthy Mother and Child Project (in cooperation with USAID). Alexandria, June 2000.
• The Annual Congress of the Egyptian Fertility and Sterility Society, Cairo, September 19th & 20th, 2000.

1999:

• Training course for Norplant service provision in family planning by the Regional Center for Training in Family Planning and Reproductive Health. Alexandria February 2nd - March 5th, 1998.
• 13th Annual Scientific Conference of the Department of Obstetrics & Gynecology. Alexandria, March, 1999.
•  4th Annual Congress of the Egyptian ICSI Centre: Fertility Management in the 21st Century. Alexandria October 28^th & 29^th, 1999.

1997:

•  ECG training course, Alexandria medical syndicate from 15/2/1997 to 15/3/1997.
• General practitioner training course , Alexandria medical syndicate from 22/3/1997 to 3/4/1997.

C- Local Courses/Conferences Organized

2009:

• Organizer: Workshop of Menopause: Treasuring the pas – shaping the future. Organized by the Menopause special interest group during the 16^th annual meeting of MEFS. Cairo, Egypt, 6 of November 2009.

2003:

• Organizer: The first annual meeting of the Egyptian Post Menopause Society, Alexandria, 31th July 2003.
• Organizer: Pre-Congress workshop on Recent Advances in The Management of Polycystic Ovarian Syndrome, for 17h Annual Scientific Conference of The Department of Obstetrics & Gynecology. Alexandria, April 8th & 9th, 2003.
• Organizer: 17h Annual Scientific Conference of The Department of Obstetrics & Gynecology. Alexandria, April 10th & 11th, 2003.

2002:

• Organizer: Low Ovarian Response in Infertility. Pre-Congress workshop to The 9th Annual Scientific Congress of The Middle East Fertility Society (MEFS), held by the Reproductive Biology and Molecular Endocrinology Interest Group, Cairo, October 28th, 2002.
• Organizer: The First Scientific Workshop on Evidence based Medicine: how to apply to Ob-Gyn Practice by The Department of Obstetrics and Gynecology, Alexandria, June 27th, 2002.

2001:

• Organizer: 16th Annual Scientific Conference of The Department of Obstetrics & Gynecology: New Perspectives in Reproductive Health. Alexandria, May 9th & 10th, 2001.
• Organizer: Workshop on Infertility, ART, and Applied Molecular Biology, Pre-Congress workshop for 15th Annual Scientific Conference of The Department of Obstetrics & Gynecology. Alexandria, April 17th & 18th, 2001.
• Organizer: 15th Annual Scientific Conference of The Department of Obstetrics & Gynecology: Reproductive Health in The 21st Century. Alexandria, April 19th & 20th, 2001.

1999:

• Organizer: 14th international annual scientific congress of the department of obstetrics and gynecology, Alexandria University. 28th - 30th April, 1999.

D. Theses supervised

• Group B streptococcal carriage, antimicrobial susceptibility, and virulence related genes among pregnant women in Alexandria, Egypt
  SM Sadaka, HA Aly, MA Meheissen, YI Orief, BM Arafa
  Alexandria Journal of Medicine 2017 | journal-article
  Publisher: Elsevier
  DOI: https://doi.org/10.1016/j.ajme.2017.01.003
• Fixed gonadotropin-releasing hormone antagonist protocol versus gonadotropin-releasing hormone agonist long protocol in patients with polycystic ovary syndrome treated for intracytoplasmic sperm injection cycles
  EEAE Khalifa, YI Orief, THM Said, DAAA Elmaksoud
  International Journal of Reproduction, Contraception, Obstetrics and ... (2016)

• Comparative study between intracytoplasmic morphologically selected sperm injection versus intracytoplasmic sperm injection in patients with severe male factor infertility and repeated intra cytoplasmic sperm injection failure
  YI Orief, MM Elabd, THM Said, NAAJ Ahmed
  International Journal of Reproduction, Contraception, Obstetrics and ... (2016)

• Evaluation of testicular volume and hormonal parameters in the prediction of testicular sperm extraction outcome in patients with nonobstructive azoospermia
  NF Agamia, DN Younan, YI Orief, SF Khalil
  Human Andrology 6 (1), 13-19 (2016)

• Will intracytoplasmic morphologically selected sperm injection replace intracytoplasmic sperm injection in cases of severe oligo-astheno-teratozoospermia?: a prospective study
  Evidence Based Women's Health Journal: February 2016 - Volume 6 - Issue 1 - p 14–20
  2016-02 | journal-article
  Publisher: Lippincott Williams & Wilkins, Inc.
  DOI: doi: 10.1097/01.EBX.0000479687.21879.db
  URL:http://journals.lww.com/ebjwh/Abstract/2016/02000/Will_intracytoplasmic_morphologically_selected.4.aspx
  YI Orief, D Younan, AS El-Agwany

• Assessment of Thyroid Function during the Three Trimesters of Pregnancy in Alexandria Region (Egypt)
  18th European Congress of Endocrinology - Munich, Germany 28 - 31 May 2016
  2016 | conference-poster
  Publisher: Lippincott Williams & Wilkins, Inc.
  DOI: 10.1530/endoabs.41.EP1077
  URL: http://www.endocrine-abstracts.org/ea/0041/ea0041EP1077.htm
  F E Amara, M H Megalaa, Y I Orief, M G Moawad, M A Korani

• Comparative Study between Three Methods of Stem Cell Separation from Cord Blood
  IJSRST , Volume 2, Issue 3
  2016 | journal-article
  ISSN: 2395-602X URL: http://ijsrst.com/paper/392.pdf.
  A Deghady, MW Ayad, Y Orief, MAB El-Shabassy

• Day-3 versus day-5 embryo transfer in intracytoplasmic sperm injection
  YI Orief, AS El-Agwany, MA Elsamra, EA Darweish, MM Ibrahim
  Journal of Evidence-Based Women’s Health Journal Society 5 (4), 180-184 (2015)

• Effect of Folic Acid Adminsteration on Plasma Homocysteine Level in Preeclampsaia among Egyptian Population
  YI Orief, AS EL, E NAYEL, MM EL SAWY, SA MORSY
  PERINATAL MEDICINE, 16 (2015)

• Relationship between ultrasound parameters and intra cytoplasmic sperm injection outcome in polycystic ovarian syndrome treated by non agonist step up stimulation protocol
  YI Orief, AS El-agwany, EAE Darwish, AHA Rahman, SM Ghazal
  Middle East Fertility Society Journal 20 (2), 102-107 (2015)

• The effect of bed rest after intrauterine insemination on pregnancy outcome
  YI Orief, AS El-agwany, EAE Darwish, NM Salim
  Middle East Fertility Society Journal 20 (1), 11-15 (2015)

• Endometrial preparation for cryoembryo transfer: effect of gonadotrophin-releasing hormone agonist coupled with estrogen and progesterone on hormonal profile and pregnancy rate
  YI Orief, EEA Khalifa, YS ElKassar, HA AL-Galal
  Journal of Evidence-Based Women’s Health Journal Society 5 (4), 157-160 (2015)

• Gestagen versus oral contraceptive pills to induce withdrawal bleeding before induction of ovulation by clomiphene citrate in polycystic ovary syndrome
  YI Orief, EAE Darwish, MA Elsamra, DHA Ragab
  Middle East Fertility Society Journal 19 (2), 115-123 (2014)

• Comparison between steroid expression in serum and follicular fluid in polycystic ovary patients and unexplained infertility patients undergoing assisted reproductive techniques
  YI Orief, TAE Karkor, HA Saleh, AS El Hadeedy, NM Ahmed
  Middle East Fertility Society Journal 19 (1), 57-63 (2014)

• Use of herbal medicines among pregnant women attending family health centers in Alexandria
  YI Orief, NF Farghaly, MIA Ibrahim
  Middle East Fertility Society Journal 19 (1), 42-50 (2014)

• Comparative evaluation of vascular endothelial growth factor-A expression in pre-ovulatory follicular fluid in normogonadotrophic and endometriotic patients undergoing assisted reproductive techniques
  YI Orief, TAE Karkor, HA Saleh, AS El Hadidy, N Badr
  Middle East Fertility Society Journal 19 (4), 248-261 (2014)

• The role of matrix metalloproteinase-2 in the culture media in embryo implantation rate in normogonadotrophic cases undergoing ICSI. Yasser Ibrahim Orief, Mohamed Mourad Alabd , Yasser Saad Alkasar ,Amr  Gamil Koritam , Akram Deghedy. Middle East Fertility SocietyJournal   (2013). http://dx.doi.org/10.1016/j.mefs.2012.11.001
   
  Amr GamilKoritam a, AkramDeghedyMiddle East Fertility SocietyJournal   (2013) http://dx.doi.org/10.1016/j.mefs.2012.11.001

• Comparison between steroid expression in serum and follicular fluid in polycystic ovary patients and unexplained infertility patients undergoing assisted reproductive techniques. Yasser Ibrahim Orief, Tarek Abd Elzaher Karkor , Hisham Aly Saleh ,Abir Shawky El Hadidy , Nahla Mahmoud Ahmed.  Middle East Fertility SocietyJournal   (2013) http://dx.doi.org/10.1016/j.mefs.2012.12.007

• Comparative evaluation of vascular endothelial growth factor-A expression in pre-ovulatory follicular fluid in normogonadotrophic and endometriotic  patients undergoing assisted reproductive techniques. Yasser Ibrahim Orief, Tarek Abd Elzaher Karkor , Hisham Aly Saleh ,Abir Shawky El Hadidy , Nana Badr.  Middle East Fertility SocietyJournal   (2013) http://dx.doi.org/10.1016/j.mefs.2013.06.002
  Abir Shawky El Hadidy c, Nana Badr

• induce withdrawal bleeding before induction of ovulation
  Gestagen versus oral contraceptive pills  to induce withdrawal bleeding before induction of ovulation by clomiphene citrate in polycystic ovary syndrome. Yasser Ibrahim Orief , Emad Abd Elmoneem Darwish, Mohamed Abdelmoaty Elsamra , Dina Hassan Aly Ragab.  Middle East Fertility SocietyJournal  (2013) http://dx.doi.org/10.1016/j.mefs.2013.06.003 

• Prevelance of hisgh risk human papilloma virus types 16/18 in cytologically abnormal cervical smears in Alexandria, Egypt. A cytological and molecular study. Mona Sobhy Elkharashy, Nagwa Gamil Rizk Mohamed , Nesrine Fathi Hanafi,Yasser Ibrahim Orief , Bassma Mohamed El Sabaa  .Middle East Fertility Society Journal (2013) 18, 253–267.

• Use of herbal medicine among pregnant women attending family health centers in Alexandria. Yasser Orief, Fatma farghaly, Mohamed ibrahim . Middle East Fertility Society Journal  2012. http://dx.doi.org/10.1016/j.mefs.2012.02.007

• Factors affecting the outcome of human blastocyst vitrification. Amr A Kader ,Audrey Choi ,Yasser Orief ,Ashok Agarwal . Reproductive Biology and Endocrinology ISSN 1477-7827, 2009, 7:99.

•  Embryo cryopreservation: Is vitrification ready to replace slow freezing? Mohamed Youssry, Yasser Orief, Vassilis Palapelas, Safaa Al-Hasani. Expert Rev. Obstet. and Gynecol. 3(4), 455-463, 2008.

•  Human sperm DNA damage in the context of assisted reproductive techniques. Mohamed Youssry, Batuhan Ozmen., Yasser Orief, Khaled Zohni , Safaa Al-Hasani.  Iranian Journal of Reproductive Medicine Vol.5. No.4. pp:137- 150, Autumn 2007.

• Evaluating three alternative protocols for improving ovarian response of he poor responders undergoing assisted reproductive techniques. MD thesis, 2006.

•  Vitrification versus conventional cryopreservation techniques, A continuous debate: Lubeck experience.Yasser Orief, Askan Schoultz Mosgou, Safaa Al-Hasani, MEFS Journal, Vol 10, No 3, 207-9, 2005.

•  Vitrification: Will it replace the conventional gamete cryopreservation techniques? Yasser Orief, Askan Schoultz Mosgou, Safaa Al-Hasani, MEFS Journal, Vol. 10, No. 3, 171-84, 2005.

•  Cryopreservation of human ovarian tissue and oocyte banking: an eye to the future. Yasser Orief, Konstantinos Dafopoulos, Safaa Al-Hasani, Pan Arab Medical Journal; 2005, Vol 3:17-22.

•  Cryopreservation of two pronuclear stage zygotes.Yasser Orief , Nikos Nikolettos , Safaa Al-Hassani.Reviews in Gynaecological Practice, 2005, Vol 5 No 1, 39-44.

•  Factors affecting outcome after ICSI with sperm retrieved from cryopreserved testicular tissue in non-obstructive azoospermia. K Dafopoulos, G Griesinger, A Schultze-Mosgau, Y Orief, B Schopper, N Nikolettos, K Diedrich, S Al-Hasani. RBM Online, Vol 10. No 4. 2005 455-460.

• Cumulative pregnancy rate after ICSI with cryopreserved testicular tissue in non-obstructive azoospermia. K Dafopoulos, G Griesinger, A Schultze-Mosgau, Y Orief, B Schopper, N Nikolettos,  K Diedrich, S Al-Hasani RBM Online, Vol 10. No 4. 2005 461-466.

• Should ICSI be used in non-male factor infertility? Yasser Orief, Konstantinos Dafopoulos, Safaa Al-Hasani .RBM Online, Volume 9, No 3, 348:356,September 2004.

•  Diagnosis of endocervical infection with Chlamydia Trachomatis using the polymerase chain reaction: comparison with chlamydial antigen detection methods.Saleh FM, Rizk AM, Ibrahim MI, and Orief YI. The Egyptian Journal of Fertility and Sterility ;2000.

• Determination of the prevalence of Chlamydia Trachomatis cervical infection in females having tubal factor of infertility. Saleh FM, Rizk AM, Ibrahim MI, and Orief YI. The Egyptian Journal of Fertility and Sterility ;2000.

• DEBATE-Vitrification versus conventional cryopreservation technique-Comment by: Yasser Orief, MD, Askan Schultze-Mosgau, MD & Safaa Al-Hasani, MD
  Y Orief, A Schultze-Mosgau, S Al-Hasani
  Middle East Fertility Society Journal 10 (3), 207-209

• Our thanks to all those who have helped with this issue of Expert Review of Obstetrics & Gynecology. Listed below are the authors, referees and others who have kindly given their time, effort and expertise; their generosity has helped establish this publication.
  M Aboulghar, N Achour-Frydman, A Agarwal, L Aghajanova, C Aguilar, ...

• Poor ovarian response: Is there an ideal protocol of management? the Egyptian Fertility Society Conference, 2004, Cairo.

•  Methods and materials used in perineal repair: an evidence based approach.The 17h Annual Scientific Conference of the Department of Obstetrics & Gynecology. Alexandria, April 8th, 9th, 2003.

• Molecular genetics in low ovarian responders. Low Ovarian Response in Infertility: Pre-Congress workshop to The 9^th Annual Scientific Congress of the Middle East Fertility Society (MEFS), held by The Reproductive Biology and Molecular Endocrinology Interest Group, Cairo, October 28th, 2002.

• Urinary tract infection in pregnancy: an easy way to manage using the Cochrane database.The First Scientific Workshop on Evidence based Medicine: how to apply to Ob/Gyn Practice, by the Department of Obstetrics and Gynecology, Alexandria, June 27th, 2002.

إن أبحاثنا و منشوراتنا الطبية في مجال علاج العقم و أطفال الانابيب نُشرت في أهم المجلات الطبية العالمية و أكثرها إنتشاراً، و تتضمن دراسات بالاضافة إلى أبحاث و محاضرات في المؤتمرات العالمية و هي إن دلت على شئ فانها تدل على تميزنا و إلتزامنا بأحدث الطرق العلمية كي نحقق لكم النجاح.

و هنا تجدون قائمة ببعض منشوراتنا و أبحاثنا الطبية.

Research has shown that many couples are uncertain, even intimidated, about initiating infertility treatment. Fears about treatment are often based on out-dated or erroneous information.

Recent improvements in medication, micro-surgery and advanced fertility treatments have made healthy pregnancy a possibility for the majority of patients who seek expert infertility advice.

Here are some treatment options:

Ovulation Induction (OI)
Intrauterine insemination
Intra-Cytoplasmic Sperm Injection (ICSI)
Assissted Hatching
Blastocyst Transfer
Testicular Biopsy (TESE)
PGS - Preimplantation Genetic Screening
Embryo Cryopreservation
Healthy Body Mind Program
Infertility and Stress
Acupuncture

There are a number of possible causes of female infertility, such as:

Polycystic Ovarian Syndrome (PCOS)
Endometriosis
Fibroids
Age

Individualised Care: 

An initial assessment of your general health will be performed and previous history will be taken before advising you which tests/investigations you need. The tests may include some or all of the following depending on what you need (a complete list will be given to you once you are a registered patient):

Blood tests (Men and Women)

1. Rubella (German Measles)
All female patients are tested for Rubella immunity. If there is no natural immunity to Rubella, then vaccination must be undertaken before commencing treatment. This eliminates the potential danger of the effects of Rubella with early pregnancy.

2. Hormone levels
Oestrogen, Luteinising Hormone, Thyroid Stimulating Hormone, Prolactin and Follicle Stimulating Hormone levels are generally tested on day 2 or 3 of your cycle prior to treatment to ensure that these are normal.

3. HIV
There are four reasons for performing this test

1) the risk of a pregnancy to a female who is infected with the virus. Pregnancy may have a negative impact on the health of an HIV positive woman.

2) the risk of transmitting the HIV virus to a child during childbirth.

3) the theoretical risk of frozen embryos / gamates transmitting the virus to other patient`s embryos / gametes

4) the risk to fertility centre staff that are handling body fluids from a large population on a daily basis. We would be required to take special precautions with samples from HIV positive patients.

4. Hepatitis B and C
Hepatitis has similar risks to HIV. Hepatitis is more infectious than HIV, although the death rate is much lower. Both partners should be tested. These tests are also of vital importance for the freezing of couples gametes and embryos.

Baseline Ultrasound Scans (Women)

A vaginal ultrasound is required. The reasons for the ultrasound are to:

1. Determine if there are any physical changes, such as fibroids or polyps, that may effect your cycle, and also check for the presence of ovarian cysts;

2. Assess the ease of 'access' to your ovaries, as your eggs will be collected using an ultrasound-guided method;

3. Provide a 'baseline' report that can be used as a reference during your treatment cycle;

4. Measure the size of your ovaries and count the number of small follicles present in your ovaries.

Occasionally you may need other baseline scans done prior to treatment cycles. Most women find a vaginal ultrasound to be a relatively painless and simple procedure. The woman's partner or a support person can be present during the procedure if she wishes. An empty bladder is required for this procedure.

Semen analysis (Men)

Two semen analyses are required. At least one semen analysis should be performed at the our laboratory prior to egg retrievalas test results can vary between laboratories and also over time. These analyses may include tests for sperm antibodies in the semen and checks for possible infection that may affect fertilisation. Details on collection of the sample will be given to you when you make your appointment. Our laboratory also does a detailed preparation to determine what the best technique for preparing your sample is.

Semen production

For some men, providing a semen sample on the day of egg collection can be quite embarrassing and stressful. We endeavour to make this event as easy as possible for you: